Researchers discover immune cell “hubs” hiding in tumors
New study hints that colorectal tumors containing these immune hubs might be more likely to respond to existing immunotherapies.
August 31, 2021

Credit: Joshua Pirl, Vjola Jorgji, Linda Nieman, Jonathan Chen. Source: Pelka, Hofree, Chen et al. Cell. 2021
In a subset of human colorectal tumors, immune cells such as activated and potentially tumor-reactive T cells (white, green, and magenta) are organized into “hubs” around malignant cells (blue) expressing molecules (yellow) that attract immune cells.