Researchers devise new way to target and correct disease-related proteins
Broad scientists built a diverse library of compounds and found one that stabilizes a dysfunctional protein in Crohn’s disease, demonstrating their library’s potential to uncover new therapeutic strategies.
Paper cited
Tan ZY, et al. Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator. Cell Chemical Biology. Online Jan 2, 2025.
Funding
The work was supported by the National Institutes of Health and The Leona M. and Harry B. Helmsley Charitable Trust.