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News-in-brief / 09.22.15

Proteomics goes subcellular: Protein labeling technique enables mapping of mitochondrial proteome in live tissues

By Broad Communications

Working with the Broad Institute’s Proteomics Platform, a team led by Norbert Perrimon of Harvard Medical School and the Broad built a novel proteomic mapping platform that they used in fruit flies. The approach uses a new protein labeling technique that is applied to live tissues, enabling the characterization of organelle proteomes. The team used the technique to map the mitochondrial matrix proteome in Drosophila muscle and then built MitoMax, a database of Drosophila mitochondrial proteins with subcompartmental annotation. Read more in PNAS.