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News-in-brief / 04.21.15

New method characterizes amplification bias in single-cell genomic DNA

By Broad Communications

In Nature Communications, a team led by researchers from the Broad Institute, MIT, and Dana-Farber Cancer Center describes new statistical methods that account for artifacts introduced by whole-genome amplification of single-cell genomic DNA. Their approach establishes a system for characterizing amplification bias and provides a framework for quality assurance in single-cell DNA libraries. Broad associate member J. Christopher Love and institute member Matthew Meyerson were senior authors of the study; Broad researchers Cheng-Zhong Zhang and Viktor Adalsteinsson were first authors.