New MCL1 protein construct solves previously intractable structural biology problem
By Broad Communications
As one of the most commonly altered genes in cancer, MCL1 has been the focus of widespread drug development efforts — but the gene, which encodes a protein that helps keep cells alive, remains an elusive target. A new finding published this week by Broad researchers is expected to catalyze the development of effective MCL1 inhibitors. The team, led by senior author Michael Serrano-Wu, designed a new MCL1 protein construct that provides a robust solution to a previously intractable structural biology problem. Their paper is published online in PLoS One.