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News-in-brief / 07.18.16

New approach speeds chemical library screens

By Broad Communications

It can take a year or more for a chemical library to be screened in cells, a delay that often slows chemists’ access to biological data that could help them plan their synthesis efforts. In the Journal of the American Chemical Society last week, a team led by Stuart Schreiber and Zarko Boskovic, of Broad’s Center for the Science of Therapeutics and Harvard University’s Department of Chemistry and Chemical Biology, shares an approach for screening newly synthesized compounds’ biological activity in near real-time. Combining chemical synthesis and cell painting, the approach could make the library design process more nimble, reveal how certain synthesis steps impact molecules’ biological activities, and accelerate drug candidate discovery.