More diverse datasets lead to better genetic risk prediction for heart disease
By using genetic data on multiple traits from people of non-European ancestry, scientists have improved the accuracy of polygenic scores in predicting disease risk for all.
This work was funded in part by Harvard Catalyst; the Sarnoff Cardiovascular Research Foundation Fellowship; the National Heart, Lung, and Blood Institute; the American Heart Association; the European Union; the National Human Genome Research Institute; a Hassenfeld Scholar Award from the Massachusetts General Hospital; and the Merkin Institute Fellows Program at the Broad Institute of MIT and Harvard.
Patel A, et al. A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease. Nature Medicine. Online July 6, 2023.