Low oxygen levels restore balance and coordination in a mouse model of a movement disorder
New study suggests that treatments that mimic the effects of a low-oxygen environment could one day help reverse Friedreich’s ataxia.

Credit: Susanna Hamilton, Broad Communications
Funding
This work was supported in part by the Friedreich’s Ataxia Research Alliance, Marriott Family Foundation, and the National Institutes of Health.
Papers cited
Ast T et al. Continuous, but not intermittent, regimens of hypoxia prevent and reverse ataxia in a murine model of Friedreich’s ataxia. Human Molecular Genetics. Online June 1, 2023. DOI:10.1093/hmg/ddad091.
Rogers RS et al. Hypoxia extends lifespan and neurological function in a mouse model of aging. PLOS Biology. Online May 23, 2023. DOI:10.1371/journal.pbio.3002117.