Improved prime editing system makes gene-sized edits in human cells at therapeutic levels
The gene-editing approach uses prime editors and evolved enzymes called recombinases, and could pave the way to effective one-size-fits-all gene therapies for diseases such as cystic fibrosis.

Credit: Susanna Hamilton, Broad Communications
Funding
This work was supported in part by the National Institutes of Health, the Bill and Melinda Gates Foundation, and the Howard Hughes Medical Institute.
Paper cited
Pandey S, Gao XD, et al. Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing. Nature Biomedical Engineering. Online June 10, 2024. DOI:10.1038/s41551-024-01227-1.