Gene expression signatures indicate loss of function by master regulators of the genome
Study findings may help researchers predict which patients with tumors may benefit from certain drug candidates.
This work was supported in part by awards from the National Institutes of Health; the American Cancer Society; the Pew-Stewart Scholars in Cancer Research; and the Klarman Cell Observatory.
Otto JE, Ursu O et al. Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation screens. Molecular Cell. Online April 6, 2023. DOI: 10.1016/j.molcel.2023.03.013