Evolved prime editors are smaller and more efficient for therapeutic applications
Researchers have evolved the editing machine at the heart of the prime editing system, which can make a wide range of changes to the genome.
Support for the study was provided in part by the National Institutes of Health, the Bill and Melinda Gates Foundation, the St. Jude Collaboration Research Consortium, the Friedreich’s Ataxia Accelerator, the Howard Hughes Medical Institute, the Hertz Foundation, the NSF Graduate Research Fellowship Program, a Ruth L. Kirschstein National Research Service Awards Postdoctoral Fellowship, an HHMI Hanna Gray Fellowship, the Bill and Melinda Gates Foundation, the Saint Baldrick’s Foundation, and the Kidz1stFund.
Doman JL, Pandey S, et al. Phage-assisted evolution and protein engineering yield compact, efficient prime editors. Cell. Online August 31, 2023. DOI: 10.1016/j.cell.2023.07.039