Cellular atlas built to guide precision treatment of rheumatoid arthritis
Analysis of more than 314,000 cells from rheumatoid arthritis tissue defines six types of inflammation involving diverse cell types and disease pathways
This work was supported by the Accelerating Medicines Partnership (AMP) in Rheumatoid Arthritis and Lupus Network, a public- private partnership (AbbVie, Arthritis Foundation, Bristol-Myers Squibb Company, Foundation for the National Institutes of Health, GlaxoSmithKline, Janssen Research and Development, Lupus Foundation of America, Lupus Research Alliance, Merck Sharp and Dohme, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Pfizer, Rheumatology Research Foundation, Sanofi and Takeda Pharmaceuticals International). Funding was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Human Genome Research Institute.
Zhang F, et al. “Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.” Nature. Online November 8, 2023. DOI: 10.1038/s41586-023-06708-y.