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News-in-brief / 03.15.16

Researchers publish system-wide analysis of T-cell response in zebrafish

By Broad Communications

A study led by Francisco Quintana of Brigham and Women’s Hospital and the Broad Institute used zebrafish as a model to examine T-cell receptors (TCRs) and their response to foreign and native antigens. The team found that a general pool of “public” TCRs capable of dealing with diverse antigen threats dominate the T-cell response in zebrafish. It’s possible that these TCR “first-responders” buy time, giving the immune system a short window during which it can develop more specialized, “private” TCRs. 

The paper appears online in Cell Reports