MitoCarta3.0: An Inventory of Mammalian Mitochondrial Proteins and Pathways
MitoCarta3.0 is an inventory of 1136 human and 1140 mouse genes encoding proteins with strong support of mitochondrial localization, now with sub-mitochondrial compartment and pathway annotations. To generate this inventory, we performed mass spectrometry of mitochondria isolated from fourteen tissues, assessed protein localization through large-scale GFP tagging/microscopy, and integrated these results with six other genome-scale datasets of mitochondrial localization, using a Bayesian approach. MitoCarta3.0, released 2020, uses manual literature curation to revise the previous MitoCarta2.0 inventory (78 added and 100 removed genes), provide annotation of sub-mitochondrial localization, and assign genes to a custom ontology of 149 mitochondrial pathways.
Excel database containing detailed information on the 1136 mitochondrial human genes including sub-mitochondrial localization and pathways, as well as integrated scores of mitochondrial localization for all ~20,000 human genes
Excel database containing detailed information on the 1140 mitochondrial mouse genes including sub-mitochondrial localization and pathways, as well as integrated scores of mitochondrial localization for all ~20,000 mouse genes
Rath, S.,* Sharma, R.*, Gupta, R.*, ..., Calvo, S.E., Mootha, V.K.. MitoCarta3.0: An updated inventory of the mitochondrial proteome, now with sub-organelle localization and pathway annotations (2020). Nucleic Acids Research [Pubmed: 33174596]
Calvo, S.E., Klauser, C.R., Mootha, V.K. MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins (2015). Nucleic Acids Research [doi: 10.1093/nar/gkv1003]
Pagliarini, D.J., Calvo, S.E., Chang, B., Sheth, S.A., Vafai, S.B., Ong, S.E., Walford, G.A., Sugiana, C., Boneh, A., Chen, W.K., et al. (2008). A mitochondrial protein compendium elucidates complex I disease biology. Cell 134, 112-123. [Pubmed: 18614015]