ML4H Publications
2024
Electrocardiogram-Based Artificial Intelligence to Discriminate Cardioembolic Stroke and Stratify Risk of Atrial Fibrillation After Stroke
Circulation: Arrhythmia and Electrophysiology
S. Khurshid, S. F. Friedman, S. Kany, R. Mahajan, A. C. Turner, S. A. Lubitz, M. Maddah, P. T. Ellinor, and C. D. Anderson.
Noninvasive assessment of organ-specific and shared pathways in multi-organ fibrosis using T1 mapping
Nature Medicine
V. Nauffal, M. D. R. Klarqvist, M. C. Hill, D. F. Pace, P. Di Achille, S. H. Choi, J. T. Rämö, J. P. Pirruccello, P. Singh, S. Kany, C. Hou, K. Ng, A. A. Philippakis, P. Batra, S. A. Lubitz and P. T. Ellinor
Deep learning of left atrial structure and function provides link to atrial fibrillation risk
Nature Communications
J. P. Pirruccello, P. Di Achille, S. H. Choi, J. T. Rämö, S. Khurshid, M. Nekoui, S. J. Jurgens, V. Nauffal, S. Kany, FinnGen, K. Ng, S. F. Friedman, P. Batra, K. L. Lunetta, A Palotie, A. A. Philippakis, J. E. Ho, S. A. Lubitz and P. T. Ellinor
Cardiovascular Significance and Genetics of Epicardial and Pericardial Adiposity,
JAMA Cardiology
J. T. Rämö, S. Kany, C. R. Hou, S. F. Friedman, C. Roselli, V. Nauffal, S. Koyama, J. Karjalainen, M. Maddah, A. Palotie, P. T. Ellinor, J. P. Pirruccello
Frequency of Electrocardiogram-Defined Cardiac Conduction Disorders in a Multi-Institutional Primary Care Cohort,
JACC Advances
J. S. Haimovich, P. D. Achille, V. Nauffal, P. Singh, C. Reeder, X. Wang, G. Sarma, J. Kornej, E. J. Benjamin, A. Philippakis, P. Batra, P. T. Ellinor, S. A. Lubitz, S. Khurshid
2023
Deep Learning-Enabled Assessment of Left Heart Structure and Function Predicts Cardiovascular Outcomes,
Journal of the American College of Cardiology
E. S. Lau, P. Di Achille, K. Kopparapu, C. T. Andrews, P. Singh, C. Reeder, M. Al-Alusi, S. Khurshid, J. S. Haimovich, P. T. Ellinor, M. H. Picard, P. Batra, S. A. Lubitz, and J. E. Ho
Deep learned representations of the resting 12-lead electrocardiogram to predict V̇O2 at peak exercise,
European Journal of Preventive Cardiology
S. Khurshid, T. W Churchill, N. Diamant, P. Di Achille, C. Reeder, P. Singh, S. F Friedman, M. M Wasfy, G. A Alba, B. A Maron, D. M Systrom, B. M Wertheim, P. T Ellinor, J. E Ho, A. L Baggish, P. Batra, S. A Lubitz, J S. Guseh
Natural Language Processing for Adjudication of Heart Failure Hospitalizations in a Multi-Center Clinical Trial,
JAMA Cardiology
Cunningham, J. W., Singh, P., Reeder, C., Claggett, B., Marti-Castellote, P. M., Lau, E. S., Khurshid, S., Batra, P., Lubitz, S. A., Maddah, M., Philippakis, A., Desai, A. S., Ellinor, P. T., Vardeny, O., Solomon, S. D., & Ho, J. E.
The Genetic Determinants of Aortic Distention,
Journal of the American College of Cardiology
J. P. Pirruccello, J. T. Rämö, S. H. Choi, M. D. Chaffin, S. Kany, M. Nekoui, E. L. Chou, S. J. Jurgens, S. F. Friedman, D. Juric, J. R. Stone, P. Batra, K. Ng, A. A. Philippakis, M. E. Lindsay, and P. T. Ellinor
Genetic Susceptibility to Atrial Fibrillation Identified via Deep Learning of 12-lead Electrocardiograms,
Circulation: Genomic and Precision Medicine
X. Wang, S. Khurshid, S. H. Choi, S. Friedman, L.-C. Weng, C. Reeder, J. P. Pirruccello, P. Singh, E. S. Lau, R. Venn, N. Diamant, P. Di Achille, A. Philippakis, C. D. Anderson, J. E. Ho, P. T. Ellinor, P. Batra, S. A. Lubitz
Genetics of Myocardial Interstitial Fibrosis in the Human Heart and Association with Disease,
Nature Genetics
V. Nauffal, P. Di Achille, M. D. R. Klarqvist, J. W. Cunningham, M. C. Hill, J. P. Pirruccello, L-C. Weng, V. N. Morrill, S. H. Choi, S. Khurshid, S. F. Friedman, M. Nekoui, C. Roselli, K. Ng, A. A. Philippakis, P. Batra, P. T. Ellinor & S. A. Lubitz
DropFuse: A Cross-Modal Autoencoder Framework Learns Holistic Representations of Cardiovascular State,
Nature Communications
A. Radhakrishnan, S. F. Friedman, S. Khurshid, K. Ng, P. Batra, S. Lubitz, A. Philippakis, C. Uhler
Clinical and Genetic Associations of Deep Learning-Derived Cardiac Magnetic Resonance-Based Left Ventricular Mass,
Nature Communications
S. Khurshid, J. Lazarte, J.P. Pirruccello, L.-C. Weng, S. H. Choi, A. W. Hall, X. Wang, S. F. Friedman, V. Nauffal, K. J. Biddinger, K. G. Aragam, P. Batra, J. E. Ho, A. A. Philippakis, P. T. Ellinor & S. A. Lubitz
Artificial Intelligence Enabled Classification of Hypertrophic Heart Diseases Using Electrocardiograms,
Cardiovascular Digital Health Journal
J. S. Haimovich, N. Diamant, S. Khurshid, P. D. Achille, C. Reeder, S. Friedman, P. Singh, W. Spurlock, P. T. Ellinor, A. Philippakis, P. Batra, J. E. Ho, S. A. Lubitz
Natural Language Processing for Adjudication of Heart Failure in the Electronic Health Record,
JACC: Heart Failure
J. W. Cunningham, P. Singh, C. Reeder, E. S. Lau, S. Khurshid, X. Wang, P. T. Ellinor, S. A. Lubitz, P. Batra, and J. E. Ho
2022
One clinician is all you need: Data-Efficient NLP Measurement Extraction from Cardiac MRI Reports,
JMIR Medical Informatics
P Singh, J Haimovich, C Reeder, S Khurshid, ES Lau, JW Cunningham, A Philippakis, CD Anderson, JE Ho, SA Lubitz, P Batra
Deep learning on resting electrocardiogram to identify impaired heart rate recovery,
Cardiovascular Digital Health Journal
N. Diamant, P. Di Achille, L-C Weng, E. S Lau, S. Khurshid, S. Friedman, C. r Reeder, P. Singh, X. Wang, G. Sarma, M. Ghadessi, J. Mielke, E. Elci, I. Kryukov, H. M Eilken, A. Derix, P.T Ellinor, C. D Anderson, A. A Philippakis, P. Batra, S. A Lubitz, J. E Ho
Genetic analysis of right heart structure and function in 40,000 people,
Nature Genetics
J. P. Pirruccello, P. D. Achille, V. Nauffal, M. Nekoui, S. F. Friedman, M. D. R. Klarqvist, M. D. Chaffin, L.-C. Weng, J. W. Cunningham, S. Khurshid, C. Roselli, H. Lin, S. Koyama, K. Ito, Y. Kamatani, I. Komuro, The BioBank Japan Project, S. J. Jurgens, E. J. Benjamin, P. Batra, P. Natarajan, K. Ng, U. Hoffmann, S. A. Lubitz, J. E. Ho, M. E. Lindsay, A. A. Philippakis, P. T. Ellinor
Spatially Distinct Genetic Determinants of Aortic Dimensions Influence Risks of Aneurysm and Stenosis
Journal of the American College of Cardiology
M. Nekoui, J. P. Pirruccello, P. Di Achille, S. H. Choi, S. N. Friedman, V. Nauffal, K. Ng, P. Batra, J. E. Ho, A. A. Philippakis, S. A. Lubitz, M. E. Lindsay, P. T. Ellinor
A Deep Learning Model for Inferring Elevated Pulmonary Capillary Wedge Pressures From the 12-Lead Electrocardiogram,
JACC: Advances
D. E. Schlesinger, N. Diamant, A. Raghu, E. Reinertsen, K. Young, P. Batra, E. Pomerantsev, and C. M. Stultz
Development of a Prediction Model for Ascending Aortic Diameter Among Asymptomatic Individuals
JAMA
J. P. Pirruccello, H. Lin, S. Khurshid, M. Nekoui, L.-C. Weng, R. S. Vasan, E. M. Isselbacher, E. J. Benjamin, S. A. Lubitz, M. E. Lindsay, P. T. Ellinor
Estimating body fat distribution - a driver of cardiometabolic health - from silhouette images
npj - digital medicine
M. D.R. Klarqvist, S. Agrawal, N. Diamant, P. T. Ellinor, A. Philippakis, K. Ng, P. Batra, and A. V. Khera
ECG-Based Deep Learning and Clinical Risk Factors to Predict Atrial Fibrillation
Circulation
S. Khurshid, S. Friedman, C. Reeder, P. Di Achille, N. Diamant, P. Singh, Lia X. Harrington, X. Wang, M. A. Al-Alusi, G. Sarma, A. S. Foulkes, P. T. Ellinor, C. D. Anderson, J. E. Ho, A. A. Philippakis, P. Batra, and S. A. Lubitz.
Deep learning enables genetic analysis of the human thoracic aorta,
Nature Genetics
J. P. Pirruccello, M. D. Chaffin, E. L. Chou, S. J. Fleming, Honghuang Lin, M. Nekoui, S. Khurshid, S. F. Friedman, A. G. Bick, Alessandro Arduini, L-C Weng, S. H. Choi, A-D Akkad, P. Batra, N. R. Tucker, A. W. Hall, C. Roselli, E. J. Benjamin, S. K. Vellarikkal, Rajat M. Gupta, C. M. Stegmann, D. Juric, J. R. Stone, R. S. Vasan, J. E. Ho, U. Hoffmann, S. A. Lubitz, A. A. Philippakis, M. E. Lindsay, and P. T. Ellinor.
Patient contrastive learning: A performant, expressive, and practical approach to electrocardiogram modeling,
PLOS Computational Biology
N. Diamant, E. Reinertsen, S. Song, A. D. Aguirre, C. M. Stultz, and P. Batra.
2021
S. Khurshid, S. Friedman, J. P. Pirruccello, P. D. Achille, N. Diamant, C. D. Anderson, P. T. Ellinor, P. Batra, J. E. Ho, A. A. Philippakis, and S. A. Lubitz.
Cardiovascular Digital Health Journal
npj - digital medicine
S. Khurshid, C. Reeder, L. X. Harrington, P. Singh, G. Sarma, S. F. Friedman, P. Di Achille, N. Diamant, J. W. Cunningham, A. C. Turner, E. S. Lau, J. S. Haimovich, M. A. Al-Alusi, X. Wang, M. D. R. Klarqvist, J. M. Ashburner, C. Diedrich, M. Ghadessi, J. Mielke, H. M. Eilken, A. McElhinney, A. Derix, S. J. Atlas, P. T. Ellinor, A. A. Philippakis, C. D. Anderson, J. E. Ho, P. Batra, and S. A. Lubitz.
Cell Genomics
M. E. Haas, J. P. Pirruccello, S. N. Friedman, M. Wang, C. A. Emdin, V. H. Ajmera, T. G. Simon, J. R. Homburger, X. Guo, M. Budoff, K. E. Corey, A. Y. Zhou, A. Philippakis, P. T. Ellinor, R. Loomba, P. Batra, and A. V. Khera.
2020
Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy
Nature Communications
J. P. Pirruccello, A. Bick, M. Wang, M. Chaffin, S. Friedman, J. Yao, X. Guo, B. A. Venkatesh, K. D. Taylor, W. S. Post, S. Rich, J. A. C. Lima, J. I. Rotter, A. Philippakis, S. A. Lubitz, P. T. Ellinor, A. V. Khera, S. Kathiresan, and K. G. Aragam