Lander Lab

In the Lander Lab, we’re interested in all aspects of how the human genome works in health and disease, including discovering and understanding: (1) the molecular basis of rare genetic diseases, common diseases and cancer; (2) genetic variation, population history and evolutionary forces in the human population; (3) key regulatory mechanisms that control the expression of genes, including the functions of and interactions among promoters, enhancers, long non-coding RNAs, epigenetic factors, and the three-dimensional folding of the genome; (4) the genes underlying specific cellular processes involved in human diseases; and (5) the cellular programs that govern cell fate transition at single cell resolution.

To do so, we develop and employ the latest advances in genomics, epigenomics, genome editing technology, and computational biology.