The Klarman Cell Observatory (KCO) is led by Broad core faculty member and MIT associate professor Aviv Regev. It has a dedicated team that is pursuing projects in a variety of cell types together with collaborators from throughout the Broad community and beyond.

The KCO pursues three major goals:

  • Develop and deploy experimental and computational approaches for systematically defining cellular circuits. These include capabilities – in the KCO and across the Broad’s Platforms – for measuring all cellular components and their connections, reconstructing circuit models, and producing and delivering perturbing agents to cells.
  • Execute Cell Observatory Projects, to reconstruct circuits in mammalian cells.
    • Flagship Projects to construct the full circuitry of key cell types.
    • Collaborative Projects to tackle only specific parts of the circuitry, learning how to overcome key challenges and address key questions.
    • KCO-Leveraged Projects use our capacity and expertise in the context of various projects, These projects are often initiated through a small, short-term collaboration to help with a particular technique, and are expanded, if appropriate, to a larger project.

      All of these projects are undertaken in collaboration with scientists in the Broad community, drawing on their deep expertise in a biological system

  • Broad Institute-ISF Partnership for Cell Circuit Research, a joint program with the Israel Science Foundation to tackle major challenges in cell circuitry, that includes collaborative projects, a postdoctoral training program, and an annual symposium for Israeli and Broad scientists.