The mission of the Bacterial Genomics Group at Broad is to develop and implement 'omics methodologies to answer pressing questions related to bacteria and their role in human health. A major focus is the evolution and spread of bacterial pathogens (and antibiotic resistance) including the interactions that these pathogens have with their host and host-associated microbiota. We devise and carry out large-scale studies that employ genomic, metagenomic and transcriptomic data sets to understand human pathologies caused by e.g., Mycobacterium tuberculosis, carbapenem resistant Enterobacteriaceae, the enterococci and uropathogenic Escherichia coli. We do this in close collaboration with clinical, academic and industry researchers from across the Broad community and around the globe. Click on the links below to learn more about specific projects.
Sequencing geographically and phenotypically diverse M. tuberculosis isolates to understand the evolution and determinants of drug resistance.
Sequencing diverse strains of Enterococcus to understand the evolution of normally commensal bacteria into antibiotic-resistant, hospital-adapted pathogens.