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Neurodegenerative and Neuropsychiatric Disorders

Inflammation of the nervous system is known to be involved in the pathology of diseases such as multiple sclerosis. In addition, genetic evidence clearly points to a role for immune pathways in several “non-immune” neurologic conditions, such as complement playing a role in schizophrenia and the receptor TREM2 expressed on microglia, the brain’s macrophage population, modulating Alzheimer’s disease. The neuroimmune group of the Immunology Program brings together investigators working across this spectrum of diseases to address common questions regarding the underlying genetics and the cellular and molecular changes involved in both healthy and dysfunctional neurologic development and homeostasis.

Team : Nir Hacohen, Vijay Kuchroo, Nikolaos Patsopoulos, Aviv Regev, Morgan Sheng, Beth Stevens, Xiao Wang, Ramnik Xavier