The Hung laboratory combines chemical and genomic approaches to define host-pathogen interactions and to reveal the critical pressure points of infectious disease. By using small organic molecules and applying systematic genetic perturbations, the lab hopes to gain new insight into bacterial responses to host immunity and chemotherapy and to establish new therapeutic paradigms for a variety of devastating pathogens, including Klebsiella pneumoniae, Pseudomonas aeruginosa and Mycobacterium tuberculosis.