Hung Lab

The Hung laboratory combines chemical and genomic approaches to define host-pathogen interactions and to reveal the critical pressure points of infectious disease.

By using small organic molecules and applying systematic genetic perturbations, the lab hopes to gain new insight into bacterial responses to host immunity and chemotherapy and to establish new therapeutic paradigms for a variety of devastating pathogens, including Klebsiella pneumoniae, Pseudomonas aeruginosa and Mycobacterium tuberculosis.

Hung Lab

Primary Investigator

Deborah T. Hung

Core Member and Co-Director of the Infectious Disease and Microbiome Program at the Broad Institute of MIT and Harvard

Professor in the Department of Genetics at Harvard Medical School

Professor in the Department of Molecular Biology at Massachusetts General Hospital

 

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Primary contacts

dhung@broadinstitute.org

Marissa Jenko, Administrative Assistant
mjenko@broadinstitute.org

Recent publications

Other Hung Lab publications
Accelerating global innovation to address antibacterial resistance: introducing CARB-X.
Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors.
A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes.
Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses.
Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis.
Bacterial toxins and small molecules elucidate endosomal trafficking.
Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth.
Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response.
Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model.
Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32.

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