Gene Regulation Observatory (GRO)

A mere 1% of the human genome encodes protein-coding genes. The remaining non-coding regions are replete with regulatory elements that control gene activity, determine cellular states, and underlie most human diseases.

There has been significant progress towards cataloging these regulatory regions and thereby identifying the working parts of the non-coding genome. These efforts to define a non-coding atlas have made apparent the need to further our understanding of the context-specific functions, mechanisms, and regulatory interactions of each element.

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The GRO supports integrated flagship projects focused on discovering and resolving functional elements, charting their interacting transcription factors (TFs), physical organization, and assembly of gene regulatory circuits. The center will integrate a comprehensive atlas of non-coding regulatory elements and refine models of gene regulation in partnership with computational biologists in the machine learning and AI space. The GRO also aims to partner with other programs and centers in the Broad community to investigate the functions of elements and genetic variants in specific biological contexts and diseases.

The GRO is co-led by Broad Institute Member Brad Bernstein, who is also chair of the Department of Cancer Biology at Dana Farber Cancer Institute, professor in cell biology and pathology at Harvard Medical School, and holds the Richard and Nancy Lubin Chair, Broad Associate Member Jason Buenrostro, who is a professor at Harvard's Department of Stem Cell and Regenerative Biology, and Liz Gaskell, the GRO’s Director of Operations and Strategy. Learn more about the GRO community and ongoing research at


Partner Programs & Centers

Cell Circuits
Klarman Cell Observatory (KCO)
Novo Nordisk Foundation Center
Eric and Wendy Schmidt Center


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