# TransmissionDisequilibriumTest

Wittkowski transmission disequilibrium test

## Overview

This annotation indicates the presence of a genetic linkage between a genetic marker and a genetic trait.

### Statistical notes

The calculation is based on the derivation described in http://en.wikipedia.org/wiki/Transmission_disequilibrium_test#A_modified_version_of_the_TDT.

Note that this annotation requires a valid ped file.

### Caveat

• This annotation requires a valid pedigree file.
• This annotation can only be used with VariantAnnotator (not with UnifiedGenotyper or HaplotypeCaller).