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# DepthPerSampleHC

Depth of informative coverage for each sample.

## Overview

This annotation is similar to the sample-level DP annotation, which counts read depth after general filtering, but with an extra layer of stringency. Its purpose is to provide the count of reads that are actually considered informative by HaplotypeCaller (HC), using pre-read likelihoods that are produced internally by HC.

In this context, an informative read is defined as one that allows the allele it carries to be easily distinguished. In contrast, a read might be considered uninformative if, for example, it only partially overlaps a short tandem repeat and it is not clear whether the read contains the reference allele or an extra repeat.

See the method documentation on using coverage information for important interpretation details.

### Caveats

• This annotation can only be generated by HaplotypeCaller (it will not work when called from VariantAnnotator).

### Related annotations

• DepthPerAlleleBySample calculates depth of coverage for each allele per sample (AD).
• Coverage gives the filtered depth of coverage for each sample and the unfiltered depth across all samples.