Lander was one of the principal leaders of the international Human Genome Project (HGP) from 1990 to 2003, with his center being the largest contributor to the mapping and sequencing of the human blueprint.
With his colleagues, Lander has developed and applied methods for discovering the molecular basis of rare genetic diseases, common diseases, and cancer. He has done work on genetic variation, population history, evolutionary forces, regulatory elements, long non-coding RNAs, three-dimensional folding of the human genome, and methods to systematically identify the genes essential for biological processes.
- Initial sequencing and analysis of the human genome (Nature, 2001)
- High-resolution haplotype structure in the human genome (Nature genetics, 2001)
- Initial sequencing and comparative analysis of the mouse genome (Nature, 2002)
- Genetic mapping in human disease (Science, 2008)
- Comprehensive mapping of long-range interactions reveals folding principles of the human genome (Science, 2009)
- Genetic screens in human cells using the CRISPR-Cas9 system (Science, 2014)
- A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping (Cell, 2014)
- Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes (PNAS, 2015)
- Identification and characterization of essential genes in the human genome (Science, 2015)
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