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SUGAR-MGH (Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans)

Broad researchers collaborate on the SUGAR-MGH study, which measures the influence of genetics on the response to two medications commonly used in the treatment of type 2 diabetes: metformin and glipizide. The completed study is a novel resource of clinical, physiological, genetic and biochemical data collected before and after the administration of these medications. Ongoing analyses within SUGAR-MGH aim to characterize genetic influences on pharmacological perturbations and help establish the functional relevance of newly discovered genetic loci to the treatment of type 2 diabetes.