Diabetic kidney disease is a devastating complication of diabetes. It is the leading cause of renal failure in the US, and a major reason for premature mortality. At the Broad, we are invested in understanding its genetic causes, as a potential path to improved prevention, monitoring and treatment.
The GENIE Consortium assembles collaborators from the Broad, University of Helsinki, Queen’s University Belfast, University College Dublin, University of Michigan, and University of Pennsylvania to identify genetic determinants of diabetic kidney disease, elucidate their molecular function, and characterize their pathogenic mechanism in humans. With funds from the JDRF, GENIE contributed to form the Diabetic Nephropathy Collaborative Research Initiative, which is conducting the largest genome-wide association study of diabetic kidney disease in type 1 diabetes.