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T2D-GENES and GoT2D

Since 2010, the Diabetes Research Group has been a central partner in the T2D-GENES and GoT2D consortia. T2D-GENES (Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples) is an NIDDK-funded research consortium that seeks to identify genetic variants for type 2 diabetes (T2D) through multiethnic sequencing studies. The original T2D-GENES effort was composed of three major experiments:

  1. Deep whole-exome sequencing in 10,000 people from five ethnicities (African-American, East Asian, South Asian, European, and Hispanic).
  2. Deep whole-genome sequencing of 600 individuals selected from extended Mexican-American pedigrees.
  3. A trans-ethnic fine-mapping "mega-meta-analysis."

The GoT2D (Genetics of Type 2 Diabetes) consortium aims to understand the allelic architecture of type 2 diabetes through whole-genome sequencing, high-density SNP genotyping, and imputation. The reference panel based on this work is intended as a comprehensive inventory of low-frequency variants in Europeans, including SNPs, small insertions and deletions, and structural variants.

These two projects have been combined to open an initial window of the genetic architecture of T2D. Currently, the project is going beyond the 13,000 sequenced whole exomes to a new dataset of 52,000 multi-ethnic exomes.