Channel Therapeutics (CHArT)

Ion channels are biological membrane proteins that control the flux of ions (charged atoms) and play crucial roles in all fundamental cell processes including neurotransmission, gene regulation and sensory transduction. The CHArT working group brings together a community within the Broad Institute of researchers with a special interest in ion channels from both biological and therapeutic perspectives.

Our core activity is a seminar series designed to foster the exchange of scientific ideas and technical expertise, as well as provide opportunities for collaboration particularly within the local Boston research ecosystem. These seminars are held periodically throughout the academic year on selected Tuesdays in the Olympus room. Please write to to be added to our mailing list.

Past CHArT Speakers



Dr. Bruce Bean

Robert Winthrop Professor of Neurobiology at Harvard University

Ion Channels to Control Neuronal Hyperexcitability
Dr. David Corey

Bertarelli Professor of Translational Medical Science
Investigator, Howard Hughes Medical Institute

A Sound-Activated Ion Channel Complex in the Inner Ear:  Understanding and Treating Deafness
Dr. Adam Cohen

Professor of Chemistry and Chemical Biology and of Physics at Harvard University

Applications of optical electrophysiology in disease modeling and pharmacology
Dr. Diomedes Logothetis

Professor at the Department of Pharmaceutical Sciences. Northeastern University

Small molecule modulators of ion channel and GPCR activity
Dr. Gary Yellen

Professor of Neurobiology, Harvard Medical School

Reverse engineering a metabolic therapy for epilepsy: BAD and KATP channels in the brain  
Dr. Diane Lipscombe

Professor of Neuroscience, Director of Brown Institute for Brain Science (BIBS) at Brown University

RNA and DNA binding proteins that regulate cell-specific choice of functional exons in the calcium ion channel CACNA1B gene
Dr. Naoshige Uchida

Professor of Molecular and Cellular Biology at Harvard University

Multiple dopamine systems: weal and woe of dopamine
Dr. Christopher Miller

Professor of Biochemistry at Brandeis University

A weird ion channel for a weird ion: Fluoride resistance in microbiology
Dr. Yiming Zhou

affiliated with Harvard Medical School and Brigham and Woman's Hospital

TRP channels in health and disease
Dr. Alfred L. George Jr.

Director, Center for Pharmacogenomics
Professor of Pharmacology at Northwestern University, Feinberg School of Medicine

Decrypting Variants of Unknown Significance in the Channelopathies
Dr. Chinfei Chen

Associate Professor of Neurology, Harvard Medical School

Insights into the Developmental Refinement of Thalamic Circuits
Dr. Clifford Woolf

Director, F.M. Kirby Neurobiology Center, Boston Children’s Hospital
Professor of Neurology and Neurobiology, Harvard Medical School

Screening for pain-selective sodium channel blockers
Dr. Jun Chen

Senior Scientist and Head of Electrophysiology, Genentech

Evolution of the Nociceptive Ion Channel TRPA1: Functional Divergence and Conservation
Dr. Irina Vetter

Deputy Director, Centre for Pain Research, Institute for Molecular Bioscience, University of Queensland

The contribution of NaV isoforms to pain pathways: insight from venom peptides.
Dr. Ricardo Dolmetsch

VP and Global Head of Neuroscience, Novartis Institutes for Biomedical Research

Developing drugs that modulate ion channels for psychiatric and neurodevelopmental diseases
Dr. Bernardo Sabatini

Alice and Rodman W. Moorhead III Professor of Neurobiology, HHMI investigator, Harvard Medical School

Mysteries of Neurotransmission
Dr. Jeffrey R. Holt

Director of Research, Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children's Hospital

Structure, Function and Restoration of TMC1 Channels in Mechanosensory Hair Cells
Dr. Samouil Farhi

Broad Institute

Molecular and Optical tools for All-Optical Electrophysiology
Dr. Maofu Liao

Associate Professor, Department of Cell Biology, Harvard Medical School

High-resolution single-particle cryo-EM and its application in studying membrane proteins
Dr. Michael Levin

Vannevar Bush Professor, Biology Department, Director, Allen Discovery Center at Tufts, Tufts Center for Regenerative and Developmental Biology, Tufts University

Endogenous bioelectric networks enable cell cooperation toward building anatomies and away from cancer: opportunities for electroceuticals
Dr. Hao Wu

Asa and Patricia Springer Professor, Harvard Medical School, Boston Children's Hospital

Structural elucidation of the inflammasome pathway – calcium flux and pore formation

Dr. Elena Oancea

Associate Professor of Medical Science, Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University

Ion channels in black and white or how does our skin get its color



Kidney Disease