Cell Circuits and Complex Tissues
Scientists working on the Human Genome Project mapped our entire genetic code. Human geneticists used this code to pinpoint variations that underlie human disease. The next phase in our scientific understanding of human health and disease is to decipher the molecular basis of cell and tissue circuits and the impact of genetic variations on these circuits. How do the components of a circuit work together to perform their tasks? How do they malfunction and permit disease? Our goal is to develop a comprehensive and quantitative analysis of cell and tissue circuits that will enable researchers to better understand disease and develop effective new treatments.
Through the activities of the Cell Circuits Program and the Klarman Cell Observatory, Broad researchers are working to systematically define the genetic and molecular circuits in a wide range of cell types, tissues, and diseases. Researchers in the Cell Circuits Program are developing the techniques and methods needed to undertake this ambitious effort, as well as hosting external visitors to learn experimental and computational methods via the NHGRI Center for Cell Circuits. The Klarman Cell Observatory develops and shares these methods with the broader scientific community for direct biological application through a series of collaborative projects.
Cell Circuits Program
The Broad Institute's Cell Circuits Program (CCP) is a scientific community focused on systematically defining the genetic and molecular circuits of a wide range of cell types. Under the direction of Broad core faculty member Aviv Regev and institute faculty member Nir Hacohen, the CCP collaborates across the Broad and affiliated labs to map cell circuitry with the eventual goal of charting the molecular and genetic connections in any human cell type. To help create these comprehensive "wiring diagrams," the CCP works to develop systematic genome-wide approaches to interrogate the structure and function of each circuit.
- NHGRI Center for Cell Circuits (dendritic cells, embryonic stem cells, and embryoid bodies)
- T cell differentiation and activation
- Inter-individual variation of circuits in health and disease
- Gut cell atlas and circuits
- Immune cell atlas
- Hematopoiesis (precursors and differentiated cells)
- Retinal cells