A comprehensive canine genetics resource including gene and variation annotation
We are developing an in-depth, easily accessible annotation of the dog genome to support disease research. The domestic dog is an important model for a wide variety of human diseases, including cancer, inflammatory disease, cardiovascular diseases and neurological and behavioral traits. We are using RNA-Seq to generate a more complete gene set and ChIP-seq to map histone marks implicating different regulatory states in different tissues. We are integrating this new data with available SNPs, published association signals, and other existing genome annotations to generate a resource easily accessible to the research community. The annotation will be served on the CanFam3.1 genome using the UCSC browser through an already developed Track Hub along with many other data sets we maintain.