What is Oncotator?

Oncotator is a tool for annotating human genomic point mutations and indels with data relevant to cancer researchers.

How does Oncotator work?

Annotations are aggregated from the following resources:

Genomic Annotations

  • Gene, transcript, and functional consequence annotations using UCSC KnownGenes hg19 and mirBase reference sets.
  • Common SNP annotations from dbSNP (includes data from 1000 Genomes project pilot 1, 2, and 3 studies).

Protein Annotations

  • Site-specific protein annotations from UniProt.
  • Druggable target data from DrugBank.
  • Coming soon:  Functional impact predictions from PolyPhen-2.

Cancer Annotations

How do I use Oncotator?

A standalone version of Oncotator is being developed.  Check back here for updates.

In the meantime, a web-based version of Oncotator is available at http://www.broadinstitute.org/oncotator