Cancer is a complex disease of genomic alterations, exploiting many different molecular mechanisms. Fighting cancer requires a comprehensive catalog of functionally disrupted genes across all cancer types. Working closely with national and international partnerships, along with philanthropic partners, we are utilizing a range of technologies to characterize the genomes, exomes, transcriptomes, proteomes, and methylomes of a wide range of cancer types. One major effort includes The Cancer Genome Atlas (TCGA) project, for which the Broad is a Genome Data Analysis Center (GDAC). Regularly updated analyses of TCGA data can be found at our TCGA Firehose page. Results and data from our many other projects can be found in the Resource Gateway. A long-term goal of our efforts is the comprehensive characterization of over 100,000 cancers with corresponding clinical data.