Zhang Lab

In a conversation with the Broad community, core institute members Feng Zhang and David Liu, institute member and clinical geneticist Heidi Rehm, and director of global policy initiatives Bina Venkataraman considered a range of scientific, medical, ethical, and societal concerns raised by reports that a researcher in China engineered the “world’s first genetically edited babies.”

More powerful than previous methods, a new approach for tagging and harvesting DNA-associated proteins from cells could open deeper insights into transcription control.

New technique enables SHERLOCK to detect a virus directly in bodily fluids, eliminating a step that required lab equipment and expanding the platform’s potential to quickly and cheaply track pathogens such as Ebola, Zika, and Lassa fever anywhere in the world

A strip of paper can now indicate presence of pathogens, tumor DNA, or any genetic signature of interest. 100-fold greater sensitivity, the ability to detect multiple targets at once, and other new features further enhance SHERLOCK's power for detecting genetic signatures.

Researchers use CRISPR-Cas13 to cut and bind RNA, expanding the genome-editing toolbox.

DroNc-Seq — a technology that merges single-nucleus RNA sequencing with microfluidics — brings new scale to gene expression studies in complex tissues.