News 11.22.2019 How the immune system puts the brakes on allergic inflammation Two studies in mice reveal a cellular circuit that inhibits inflammation in the intestine and lungs. Food Allergy Science Initiative (FASI) Klarman Cell Observatory Metabolism Program Regev Lab Xavier Lab Immunological Disease Food allergies Single Cell News and Media Read more
Blog 10.07.2019 How to improve therapies for inflammatory bowel disease IBD researchers talk about what the field needs to do to better understand the disease and ultimately benefit more patients. Infectious Disease and Microbiome Xavier Lab Immunological Disease Infectious Disease and Microbiome Read more
News 07.25.2019 Single-cell atlas reveals underlying building blocks of ulcerative colitis Hundreds of thousands of colon cells offer new clues into what goes wrong in an inflammatory bowel disease and why some patients don’t respond to drugs HCA Klarman Cell Observatory Regev Lab Immunological Disease Single Cell News and Media Read more
News 06.10.2019 Study reveals a microbe's molecular role in Crohn's disease The bacterium Ruminococcus gnavus produces an inflammatory polysaccharide that triggers an immune response during disease flare ups. Infectious Disease and Microbiome Infectious Disease and Microbiome Inflammatory bowel disease Read more
News 05.10.2019 Research Roundup: May 10, 2019 Better targeting for base editors, an expanding encyclopedia of cancer cell lines, molecular messengers in IBD, and more. Read more
News 01.10.2019 Flippable DNA switches help bacteria resist antibiotics and are more common than thought Invertons — bits of regulatory DNA that can flip between "on" and "off" positions — let bacteria adapt to their surroundings and are widespread. Infectious Disease and Microbiome Infectious Disease and Microbiome Read more
News 11.01.2018 Crosstalk between immune and intestinal stem cells may help maintain a healthy gut A subset of intestinal stem cells communicate with T helper cells, which in turn may influence stem cells' state through the cytokines they produce. Cell Circuits Genome Regulation, Cellular Circuitry and Epigenomics Genome regulation, cell circuitry, and epigenomics Klarman Cell Observatory Infectious Disease and Microbiome Infectious Disease and Microbiome Gene-Expression Profiling Single Cell Read more
News 10.22.2018 Machine learning tool predicts peptides' potential as immune activators A deep neural network algorithm called BOTA uses bacterial genomes to identify unrecognized bacterial antigens. Infectious Disease and Microbiome Read more
News 10.10.2018 Microbiome profiling reveals associations with ulcerative colitis severity, treatment A study of gut microbes from more than 400 children points to how the microbiome behaves in this inflammatory bowel disease. Infectious Disease and Microbiome Infectious Disease and Microbiome Read more