Psychiatric Disorders

On January 9, Broad Institute was honored to host renowned neurobiologist Ben Barres.

Barres, Chairman of Neurobiology and Professor of Neurobiology, Developmental Biology, Neurology, and Ophthalmology at Stanford, visited Broad as a guest of the Stanley Center and gave a seminar entitled “What do reactive astrocytes do?” to a packed auditorium. His research has made important contributions to the role of microglia and astrocytes in the biology of the brain, in particular their role in synaptic pruning.

You can watch his talk here.

The study of structural variation — large-scale changes in DNA that can, in some cases, refashion entire chromosomes — in the genomic era has lagged behind that of sequence variation. But there’s a growing appreciation of how important structural variants are to human biology and disease. What makes these variants more challenging to study, and what is being done to overcome those challenges?