Genome regulation, cell circuitry, and epigenomics

In defining the cellular context of diffuse midline gliomas, researchers find the cells fueling their growth and suggest a potential approach to treating them: forcing their cells to be more mature.

In disease, a key gene regulator could be missing or defective. A critical epigenetic mark could be miswritten. A key circuit might be over- or under-active. We use a diverse set of tools — including genetic perturbations and genome- and proteome-wide measurements — to decipher the functions of coding and non-coding regions of the genome and study cellular circuitry, with a strong emphasis on the analysis of single cells.