Genetic Perturbation

Visitors are invited to explore galleries highlighting key discoveries and transformative insights in biomedicine.

Discovery of pro- and anti-viral host genes will help guide efforts to develop new therapies

Pooled screening in human cells and molecular understanding of Huntington’s disease and pediatric brain cancers. 

New image-based genetic screening method helps researchers identify key regulators of inflammation.

Calculating genetic risk scores for obesity, new insights about leukemia drugs, and more.

Using a new model dubbed DEMETER2, the Broad's Cancer Dependency Map team has compiled the largest dataset of genetic dependencies in cancer to date.

In explaining why mutations in the gene TP53 tend to cluster in “hot spots,” a new study lays the groundwork for ability to identify the function of any mutation in any cancer gene.

Researchers have identified an indirect way of countering a key genetic lesion in neuroblastoma.