Gene editing

Researchers have evolved the editing machine at the heart of the prime editing system, which can make a wide range of changes to the genome.

The first RNA-guided DNA-cutting enzyme found in eukaryotes, Fanzor could one day be harnessed to edit DNA more precisely than CRISPR/Cas systems.

Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard showed how prime editing can correct mutations that cause sickle cell disease in a potentially curative approach.

A one-time genome-editing treatment restores motor function and extends lifespan in an animal model of a neuromuscular disease that is the leading genetic cause of infant mortality.

With further development, the programmable system could be used in a range of applications including gene therapy and cancer therapy.

Greg Newby discusses the value of mentorship and his goals for his next career step.