David Liu

Correcting the mutation that causes progeria with base editing leads to strong symptom reduction and longer lifespan in an animal model

An engineered bacterial toxin is a key part of a gene editor that can make single-base changes in human mitochondria.

BE-Hive can tell which base editor performs best to repair thousands of disease-causing mutations

By showing they could repair a single recessive mutation behind a form of hearing loss, researchers open the door to using base editing to address a broader range of conditions

A new adenine base editor expands the range of genetic sites that can be edited in human cells, with speed and efficiency far surpassing the original editor.

New CRISPR base editors make fewer off-target edits and can access more locations on the genome than earlier versions.

“Prime editing” combines two key proteins and a new RNA to make targeted insertions, deletions, and all possible single-letter changes in the DNA of human cells

Genetic insights about autism spectrum disorder and insomnia, first cellular atlas of the primate retina, and more.

Researchers are honing genome-editing systems, discovering new ones, and envisioning versatile CRISPR tools yet to come