CRISPR

Researchers harness new pooled, image-based screening method to probe the functions of over 5,000 genes that human cells require to survive

Visitors are invited to explore galleries highlighting key discoveries and transformative insights in biomedicine.

By introducing cancer-causing mutations into healthy skin cells step-by-step, Broad scientists have created models of skin cancer that can reveal the effects of mutations.

RNA-guided enzymes are more diverse and widespread than previously believed

Converting a pathogenic hemoglobin gene to a benign variant enables healthy blood cell production in an animal model of sickle cell disease.

Correcting the mutation that causes progeria with base editing leads to strong symptom reduction and longer lifespan in an animal model

Scientists apply the “Perturb-Seq” method to a living organism for the first time

The experimental CRISPR-based test, with further development, could potentially be used outside of labs.