CRISPR

Current CRISPR guides don’t work equally well in cells from people of all ancestries, which could lead to false negative results.

Genetic alterations in cells lining blood vessels contribute to coronary artery disease, with implications for diagnostic and treatment strategies

By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.

The first RNA-guided DNA-cutting enzyme found in eukaryotes, Fanzor could one day be harnessed to edit DNA more precisely than CRISPR/Cas systems.

Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard showed how prime editing can correct mutations that cause sickle cell disease in a potentially curative approach.