Cardiovascular disease

Two teams show how inherited mutations can increase a person’s risk of accumulating sporadic mutations in their blood stem cells.

In people with a single-gene variant that puts them at high risk for heart disease, breast cancer, or colorectal cancer, the rest of the genome can alter that risk.

Study reveals surprising genomic swapping that underlies clonal hematopoiesis, a condition that can lead to blood cancer and heart disease.

Analyzing cardiac measurements from large biobanks can uncover genetic predisposition to diseases like heart failure and arrhythmias.

The finding suggests a potentially more targeted way to treat certain patients with the disorder, called CHIP, which commonly affects the elderly

A large genetic study of venous thromboembolism could lead to better ways of identifying and treating people at high risk for the disease.

Calculating genetic risk scores for obesity, new insights about leukemia drugs, and more.

Powerful new tool may enable new opportunities for biological understanding and clinical interventions

Mutations in TTN, a gene associated with several forms of heart disease and heart failure, may also play key roles in early form of a common heart arrhythmia.