• Highlights from the 2010 Annual Report: Aviv Regev focuses on how cells are “wired”

    Leah Eisenstadt, August 3rd, 2011 | Filed under

    Cells use a complex network of connections to make a constant array of decisions about their surrounding environment: Is it time to grow? Is it time to change into a different type of cell? When a cellular component or connection is missing or defective, disease takes hold.

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  • Biology visualization workshop videos now online

    Leah Eisenstadt, July 29th, 2011 | Filed under

    This spring, artists, designers, computational biologists, and software engineers gathered in the Broad Institute auditorium for three days of talks, posters, and tutorials on the cutting-edge field of visualization in biology.

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  • Getting the cover story

    Leah Eisenstadt, July 19th, 2011 | Filed under

    Back in May, we told you on the blog about Trinity, a suite of tools that assembles transcripts, or bits of RNA that have been copied from a cell’s genome, into a “transcriptome,” even without a reference genome handy.

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  • Word of the day: Biomarkers

    Leah Eisenstadt, July 7th, 2011 | Filed under

    Last week on the Broad website, we told you about a new approach to detect and verify biomarkers, using the search for signals of heart attack as a test case. In this study, the team of scientists from the Broad Institute and Massachusetts General Hospital looked for proteins in the blood that are released when heart cells are injured and that can be detected quickly after the attack.

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  • Psychiatric research accelerates at the Broad

    Leah Eisenstadt, May 18th, 2011 | Filed under

    After a storied career running a multimillion-dollar business, Ted Stanley and his wife, Vada, set up a philanthropic foundation in the 1980s to invest in good causes. Their goals became a lot more focused when their son developed bipolar disorder and needed treatment. The Stanleys considered themselves fortunate that the drug lithium successfully treated his symptoms – and they want to make sure that someday, there is a much wider range of options for others with psychiatric illness.

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  • GenePattern: Data choreographer

    Leah Eisenstadt, May 11th, 2011 | Filed under

    Six years ago, a team of researchers at the Broad faced a challenge: researchers the world over were using microarrays – chips covered with microscopic fragments of DNA – to measure the expression, or activity, of genes, but the tools to analyze the data from these large-scale studies were often out of the direct reach of biomedical researchers.

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  • How tweet it is

    Leah Eisenstadt, April 28th, 2011 | Filed under

    With nearly 125 posts to date on the Broad blog, we are now venturing out into another realm of social media: Twitter. On the Broad’s new Twitter page, you can follow news updates, press releases, blog posts, and other announcements all in one place.

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  • Broad researchers bring rare variants to light with new technique

    Leah Eisenstadt, March 9th, 2011 | Filed under

    Genome-wide association studies (GWAS) have been successful at discovering common genetic variants that are risk factors for disease or that influence traits. Although more than 1,000 genetic loci, or regions of the genome, have been associated with diseases or traits through GWAS, much of the heritability remains hidden. A disease or trait’s heritability is the degree to which it is inherited, and therefore, influenced by genetic elements; scientists often determine heritability through studies of siblings and twins to tease out genetic and environmental effects.

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  • Neandertal paper wins big

    Leah Eisenstadt, February 22nd, 2011 | Filed under

    In May 2010, a team of scientists including several Broad researchers announced they had completed a draft of the genome sequence of the Neandertal, our closest evolutionary cousin. The study, appearing in the journal Science, was big news among genomic scientists and anthropologists.

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  • Power in numbers

    Leah Eisenstadt, February 16th, 2011 | Filed under

    Earlier this month, we reported on a powerful analysis of next-generation sequencing data from the pilot phase of the 1000 Genomes Project that resulted in a rich, high-resolution map of structural variation — extra, missing, or rearranged DNA — in the human genome. That map, along with research tools created from it, will enable new studies of this kind of DNA variation in human biology and disease.

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