Smile for the camera, Cpf1

Tom Ulrich, April 21st, 2016

The crystal structure of CPF1 provides some intriguing insights into this CRISPR gene-editing enzyme.

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Cancer close-up: Single-cell approach provides detailed look inside tumors

Members of the Klarman Cell Observatory at the Broad Institute and the Joint Center for Cancer Precision Medicine (CCPM) at the Dana-Farber Cancer Institute, Brigham and Women’s Hospital, and the Broad have embarked on an ambitious effort to use single-cell genome analysis to explore

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Roads Less Traveled

Angela Page, April 13th, 2016

Zuzana Tothova has a weakness for uncharted territory. It has inspired her to pursue an ambitious project at the Broad Institute of MIT and Harvard where she’s using a slew of novel technologies to better understand a blood disorders called myelodysplastic syndrome (MDS). But this weakness for the unknown runs deep and can even be blamed for how she found herself in the United States in the first place.

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Putting a face on rare disease

Tom Ulrich, April 8th, 2016

A traveling art exhibit featuring portraits of children with rare diseases comes to the Broad this spring to humanize and inspire research on these conditions.

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From spectrum to continuum

Veronica Meade-Kelly, March 17th, 2016

New research uses genetic and behavioral data to shed light on autism-associated traits in the general population

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Broad Institute joins White House Precision Medicine Summit with researchers, initiatives to drive health research forward

Paul Goldsmith, February 25th, 2016

On Thursday, February 25th, President Obama hosted a panel discussion as part of the White House Precision Medicine Initiative Summit, which included discussions of three Broad initiatives and research projects. The summit highlighted progress made as part of the President’s Precision Medicine Initiative (PMI).

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Good apart, better together

Lisa Girard, February 11th, 2016

Synergy between two large cancer datasets may help identify a targetable weakness across many cancers

When making a simple telescope, relative adjustments between two lenses can bring previously blurry objects sharply into focus. Peering through two such “lenses” recently led to a discovery that may help identify which patients could most benefit from taking aim at a potentially widespread cancer therapeutic target.

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Enhancer hijacking means a power-up for salivary gland cancer

Angela Page, February 5th, 2016

Cancers can be cunning beasts and one of their favorite opportunities is something called a chromosomal translocation. Chromosomes are the 23 packages in every cell of condensed DNA. Translocations happen when the DNA breaks and the ends reattach elsewhere. DNA breakage actually occurs somewhat frequently, even in healthy individuals. But a series of ancient and very smart cellular processes ensure that things get put back in the right place — except when they don’t.

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Pardis Sabeti: How we'll fight the virus next time

Paul Goldsmith, February 4th, 2016

When Ebola Zaire swept across West Africa in early 2014, a research team led by Broad Institute member Pardis Sabeti worked with collaborators from Sierra Leone and around the world to collect samples, rapidly sequence genomes, and share data in order to accelerate the outbreak response effort.

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“Molecular sleds” slide cargo along DNA

Leah Eisenstadt, February 2nd, 2016

Protein interactions via a new type of biochemistry- one-dimensional biochemistry

Broad core institute member Paul Blainey recalls that toward the end of his graduate training in Chemistry and Chemical Biology at Harvard nearly a decade ago, things became really interesting. He got a request for help from a scientist who studies viruses that would later lead to their discovery of a new vehicle for intracellular transport dubbed a “molecular sled” and help chart the path of Blainey’s own scientific career.

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