Risk or resilience: the genetics of PTSD

Paul Goldsmith, September 22nd, 2016

Hysteria, nostalgia, homesickness, railroad spine, shell shock, battle fatigue—posttraumatic stress disorder has been with us for as long as recorded history. Today, PTSD is one of our most common psychiatric disorders—affecting an estimated 24 million adults in the U.S. alone. And yet, despite its prevalence, little is known about the biological roots of this debilitating condition.

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Opinionome: Can DNA sequencing get any faster and cheaper?

Tom Ulrich, September 14th, 2016

Sequencing a human genome today costs roughly 0.0014% of what it was in 2001, and takes hours instead of years. Can sequencing still get cheaper and faster? And does it need to?

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A big honor for two young innovators

Leah Eisenstadt, August 23rd, 2016

Broad scientists Sonia Vallabh and Evan Macosko have been named two of MIT Technology Review’s 2016 Innovators Under 35. Each year since 1999, the magazine has selected exceptionally talented young innovators whose work they believe has the greatest potential to transform the world.

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Divide and conquer: New single-cell approach broadens range of cell types that can be studied in the brain

Veronica Meade-Kelly, July 28th, 2016

Cell populations are remarkably diverse—even within the same tissue or cell type. Each cell, no matter how similar it appears to its neighbor, behaves and responds to its environment in its own way depending on which of its genes are expressed and to what degree. How genes are expressed in each cell—how RNA is “read” and turned into proteins—determines what jobs the cell performs in the body.

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He said, she said, the data said: Coming to consensus on genetic testing

Tom Ulrich, July 26th, 2016

As genetic tests become more widely available and widely adopted, clinical genetics is facing a crisis of consensus. But it doesn’t have to be this way.

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A model approach to tackling rare cancers

Tom Ulrich, July 6th, 2016

Researchers lack the cell line models they need to really dig into the biology of rare cancers. New efforts in in vitro modeling could change that.

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Reading vivax malaria’s global story in its genes

Tom Ulrich, June 28th, 2016

Plasmodium vivax is the chief malaria-causing parasite outside Africa, but we know relatively little about it. A study provides new insights into this neglected pathogen’s relationship with us.

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Thwarting cancer’s spread

Nicole Davis, June 27th, 2016

International team probes unique collection of early- and late-stage endometrial tumors to shed light on the biology of metastasis

A tumor’s ability to spread to other parts of the body is among its deadliest capabilities. Unfortunately, it is also one of the most poorly understood. By unlocking the biology of this process, known as metastasis, scientists hope to open up new therapeutic avenues for a variety of cancers that, once metastasized, are largely incurable.

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Opinionome: What will be the next big –ome?

Tom Ulrich, June 16th, 2016

The variety of –omes and –omic sciences has exploded in the last 20 years. Proteomics, metagenomics, transcriptomics...which –omes are on the rise?

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A massive approach to finding what's "real" in genome-wide association data

Tom Ulrich, June 2nd, 2016

What could we learn if we probed the subtle effects of thousands of DNA variations on gene expression, all at once? Two recent Cell papers hint at how an assay called MPRA could help us get there.

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