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Yu-Shan Stephanie Hsiao


Birnbaum ME, Berry R, Hsiao YS et al. Molecular architecture of the αβ T cell receptor-CD3 complex. Proc Natl Acad Sci U.S.A. 2014;111:17576–17581.

Tran TH, Hsiao YS, Jo J et al. Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase. Nature. 2015;518:120–124.

Hsiao YS, Parker D, Ratner AJ et al. Crystal structures of respiratory pathogen neuraminidases. Biochem Biophys Res Commun. 2009;380:467-71.

Hsiao YS, Jogl G, Tong L. Crystal structure of murine carnitine acetyltransferase in ternary complexes with its substrates. J Biol Chem. 2006;281:28480-28487.

Yu-Shan Stephanie Hsiao, Ph.D.

Yu-Shan Stephanie Hsiao is a research scientist in the Metabolism Program at the Broad Institute of MIT and Harvard. As a membrane protein biochemist, her research focuses on protein targets related to mitochondrial diseases. Hsiao’s research studies membrane protein targets involved in mitochondrial calcium signaling and is undertaken in collaboration with other research groups at the Broad Institute and Massachusetts General Hospital.

Prior to joining the Broad Institute in 2015, Hsiao worked in the lab of James Rocco at Massachusetts Eye and Ear Infirmary/Massachusetts General Hospital Cancer Center, focusing on evaluating epigenetic markers related to head and neck cancer.

Hsiao obtained her Ph.D. and M.Phil. in structural biology/biochemistry/biological sciences from Columbia University in New York. Her major focus was to use structural biology techniques, mainly X-ray crystallography, to elucidate the mechanism and function of biological macromolecules involved in fatty acid oxidation. She then undertook postdoctoral research in the Walz lab at Harvard University, where she studied membrane protein targets involved in mitochondrial fatty acid transport using electron microscopy. She also holds a M.S. in biochemistry from National Chiao Tung University and a B.S. in chemistry from Chung Yuan Christian University, both in Taiwan.

Contact Yu-Shan Stephanie Hsiao at

February 2017