Madison JM, Zhou F, Nigam A, et al. Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities. Mol Psychiatry. 2015;20(6):703-717.
Mullen TE, Smith SE, Graham D, et al. Norrie disease: extraocular clinical manifestations in 56 patients. Am J Med Genet A. 2012;158A(8):1909-1917.
Mullen TM, Marzluff WF. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. Genes Dev. 2008;22(1):50-65.
Thomas Mullen, Ph.D.
Tom Mullen works under the auspices of Heidi Rehm and Daniel MacArthur within the Genomics Platform and the Program in Medical and Population Genetics at the Broad Institute of Harvard and MIT. He serves the Broad Institute in two capacities: as the laboratory director for the Clinical Research Sequencing Platform, which provides genomic sequencing in a CLIA-certified, CAP-accredited laboratory, and as a senior analyst in the Broad Institute’s Center for Mendelian Genomics, which focuses on novel gene discovery.
Prior to joining the Broad Institute in 2016, Mullen was an instructor in the Department of Pathology at Massachusetts General Hospital and Harvard Medical School, where he performed clinical diagnostic work in Heidi Rehm’s Laboratory for Molecular Medicine. He later worked at Good Start Genetics, Inc. to perform carrier and preimplantation genetic screening before returning to the Broad Institute.
Mullen received a B.S. in biology from Northeastern University and then went on to obtain a M.S. in pathology at the University of Connecticut. He received his Ph.D. in biochemistry and biophysics from the University of North Carolina at Chapel Hill, working in the laboratory of Bill Marzluff. His research elucidated a widespread mechanism used by eukaryotic cells to target mRNAs for degradation by post-transcriptionally adding non-templated uridines. His graduate studies were distinguished by the Graduate School Dean's Distinguished Dissertation Award (University of North Carolina) and the Lineberger Comprehensive Cancer Center Graduate Student Fellow Award (University of North Carolina).
Following his graduate studies, Mullen undertook a Clinical Molecular Genetics (American Board of Medical Genetics and Genomics) fellowship at Harvard Medical School followed by postdoctoral research in the Department of Genetics at Harvard Medical School with Steve McCarroll.
Contact Thomas Mullen via email at email@example.com.