You are here

Stephen Johnston

Publications

Geller, LT, et al. “Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.” Science, 2017, 357(6356), 1156-1160.

Wellington, S, et al.; “A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.” Nat. Chem. Biol., 2017, 13, 943-950.

Corsello, SM, et al.; “The Drug Repurposing Hub: a next-generation drug library and information resource.” Nat. Med., 2017, 23, 405-408.

Law, JM, et al.; “Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1.” ACS Med. Chem. Lett., 2016, 7(10), 944-949.

Over, B, et al. “Structural and Conformational Determinants of Macrocycle Cell Permeability.” Nat. Chem. Biol., 2016, 12, 1065-1074.

Dockendorff, C, Falloon, PW, Pu, J et al. Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Bioorg. Med. Chem. Lett. 2015; 25(10), 2100-2105.

 

Stephen Johnston, Ph.D.

Stephen Johnston is the director of discovery solutions at the Center for the Development of Therapeutics (CDoT) of the Broad Institute of MIT and Harvard. He leads the compound management, laboratory automation, high-content imaging, and outreach screening scientific functions. He has previously held positions focusing on CDoT’s people, space, finances, and other operational and strategic needs.

Johnston’s primary scientific areas of expertise are liquid chromatography–mass spectrometry of small molecules, including assay development, purity assessment and purification, ADME, and maintenance and repair of analytical instrumentation. He also has extensive experience in the storage and distribution of small molecules for drug discovery uses including high-throughput screening. He was part of the organizing committee for the annual Boston Society HT-ADME conference from 2015 to 2019, chairing the conference in 2019.

Johnston received his bachelor’s degree in chemistry from Davidson College, followed by a doctorate in analytical chemistry from the University of North Carolina at Chapel Hill. He joined the Broad Institute in 2007. He is currently studying for an M.B.A. at the MIT Sloan School of Management.

Contact Stephen Johnston via email at johnston@broadinstitute.org.

January 2022