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Stephen Johnston

Stephen Johnston, Ph.D.

Stephen Johnston is senior group leader for analytical chemistry at the Center for the Development of Therapeutics (CDoT) of the Broad Institute of MIT and Harvard. His group provides analytical chemistry functions for early therapeutic discovery/development of small molecules, which includes assessment of the purity of synthesized or purchased small molecules, purification of them when necessary, and performing in vitro ADME assays as a first prediction of how molecules will behave in a live animal. Additionally, the group maintains the open access instrumentation for the chemist community at the Broad, and is also starting to perform mass spectrometry-based high-throughput screening assays.

Johnston received his bachelor’s degree in chemistry from Davidson College, followed by a doctorate in analytical chemistry from the University of North Carolina at Chapel Hill. He joined the Broad Institute in 2007. His primary areas of expertise are liquid chromatography–mass spectrometry of small molecules, purity assessment and purification, ADME, and maintenance and repair of analytical instrumentation. He has additional expertise in pharmacokinetics and HTS with mass spectrometric detection. He was named to the organizing committee for the HT-ADME 2015 conference at the Broad Institute on July 23, 2015.

Contact Stephen Johnston via email at

October 2015