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Sebastian Vaca

Sebastian Vaca, Ph.D.

Sebastian Vaca is a research scientist in the Proteomics Platform at the Broad Institute of MIT and Harvard working under the direction of Steve Carr. Vaca’s focus at the Broad Institute has been the development and application of quantitative mass spectrometry technologies for quantifying peptides, proteins, and post-translational modifications, such as phosphorylation in biological fluids, cells, and tissues. His research has also focused on developing new data analysis tools to improve targeted and global quantitative proteomics.

Recently, Vaca was part of the Library of Integrated Network-Based Cellular Signatures (LINCS) Program. This program focused on profiling cellular responses in the spaces of phosphosignaling and histone modifications in a highly multiplexed manner. Vaca has experience in sample-preparation automation using liquid-handling robots, analysis of large cohorts of datasets, and automating data analysis workflows. Also, he focuses on employing ion-mobility-based instrumentation to improve the selectivity and sensitivity of low-abundant proteins and to better discriminate molecules with similar physicochemical properties. Additionally, Vaca works on collaborations within and outside the Broad Institute, helping address biological problems using proteomics.

Vaca holds a Ph.D. in analytical chemistry specialized in mass spectrometry and proteomics.

Contact Sebastian Vaca via email at

February 2021