Gupta, RM*, Hadaya J, Trehan A, Zekavat SM, Roselli C, Klarin D, Emdin C, Hilvering CRE, Bianchi, V, Mueller C, Khera A, Ryan RJH, Engreitz JM, Isner R, Epstein CB, de Laat W, Brown JB, Schnabel RB, Bernstein BE, Kathiresan S*. A genetic variant associated with 5 vascular diseases is a distal regulator of Endothelin-1 gene expression. Cell. 2017, 170: 522-533.
Gupta R, Ejebe K, Butler J, Lettre G, Lyon H, Guiducci C, Wilks R, Bennett F, Forrester T, Tayo B, Musunuru K, Hirschhorn J, Kathiresan S, Cooper RS, McKenzie CA. Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica. Hum Genet. 2010, 128:557-61.
Gupta RM*, Meissner TB*, Cowan CA, Musunuru K. Genome-edited human pluripotent stem cell-derived macrophages as a model of reverse cholesterol transport. ATVB. 36:15-8.
Beaudoin M*, Gupta RM*, Won H, Lo KS, Do R, Henderson CA, Lavoie-St-Amour C, Langlois, S, Rivas D, Lehoux S, Kathiresan S, Tardif JC, Musunuru K, Lettre G. Myocardial infarction-associated SNP at 6p24 interferes with MEF2 binding and associates with PHACTR1 expression levels in human coronary arteries. ATVB. 2015, 115.
Rajat Gupta, M.D.
Rajat Gupta is a cardiologist at Brigham and Women’s Hospital and an Instructor in Medicine at Harvard Medical School. He completed his post-doctoral fellowship in the Kathiresan Lab at the Broad Institute where he identified new mechanisms of vascular disease from human genetic studies. He identified a common genetic variant associated with 5 vascular diseases, and demonstrated its regulatory effect on Endothelin-1 expression (Gupta, et al., Cell, 2017). He works with the Precision Cardiology Lab on the single cell analysis of vascular cell heterogeneity.
Gupta competed clinical training at Brigham and Women’s Hospital (Cardiology) and Massachusetts General Hospital (Internal Medicine). He received his M.D. degree from the Perlman School of Medicine at the University of Pennsylvania and a B.A. in cellular and molecular biology from the University of Michigan.