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Qi (Gail) Guo

Publications

Ranasinghe C, Guo Q, Sapienza PJ, et al. Protein mass effects on formate dehydrogenase. J Am Chem Soc. 2017;139(48):17405–17413.

Guo Q, Gakhar L, Wickersham K, et al. Structural and kinetic studies of formate dehydrogenase from Candida boidinii. Biochemistry. 2016;55(19):2760–2771.

Guo Q, Pagano P, Li Y-L, et al. Line shape analysis of two-dimensional infrared spectra. J Chem Phys. 2015;142(21):212427.

Qi (Gail) Guo, Ph.D.

Qi (Gail) Guo is a research scientist I in the structural biology group of the Center for the Development of Therapeutics (CDoT) at the Broad Institute of MIT and Harvard, working under the direction of Christopher Lemke. She uses macromolecular X-ray crystallography in combination with protein science and biophysical and biochemical tools to develop molecules that target essential proteins causing human diseases. She brings expertise in generating high-resolution structures of challenging and novel protein targets that enable the 3D visualization of the macromolecular structure at the atomic level to drive small molecule drug design.

Before joining Broad Institute in April 2017, Guo worked at Biogen as a technology investment fellow. She also participated in the graduate co-op program at Bristol-Myers Squibb during her Ph.D program.

Guo earned her Ph.D. in biophysical chemistry from the University of Iowa, where her focus was to understand how ultrafast protein dynamics affect enzyme kinetics. She holds a B.Sc. in both chemistry and economics from Peking University, China.

Contact Qi (Gail) Guo via email at qguo@broadinstitute.org.

March 2019