Namrata Udeshi, Ph.D.
Associate Platform Director
Namrata Udeshi is a research scientist and the associate director of the Proteomics Platform at the Broad Institute of MIT and Harvard. Her focus over the past >15 years has been the development of novel state-of-the-art mass spectrometry-driven technology for analysis of protein expression, interaction, and post-translational modifications. Udeshi performs unbiased analyses at nearly whole proteome coverage to decipher signaling pathways and identify key regulatory proteins in biological systems that are associated with physiological disease or drug perturbation phenotypes.
Udeshi has a strong focus in the area of protein ubiquitination and has developed proteomic methods for enrichment and quantification of ubiquitylation sites at a global scale, to routinely detect ubiquitination sites from cell or tissue samples. The developed techniques have been critical for the identification of ubiquitin ligase substrates and have revealed key transcription factors modulated upon lenalidomide treatment in myeloma, as well as substrates targeted by recurrently mutated ligases in prostate cancer. Udeshi also uses and develops proteomic methods to identify proteins from enzyme-mediated proximity biotinylation.
Udeshi completed her Ph.D. in chemistry from the University of Virginia under the direction of Donald F Hunt. She joined the Broad Institute in 2009 as a postdoctoral associate with Steven Carr. Udeshi holds a B.A. in both chemistry and economics from Boston University.