Namrata Udeshi

Namrata Udeshi, Ph.D.

Namrata Udeshi

Namrata Udeshi is the associate director of the Proteomics Platform at the Broad Institute of MIT and Harvard, where she is an institute scientist. Her focus over the past 20 years has been the development of novel state-of-the-art mass spectrometry-driven technology for analysis of protein expression, interaction, and post-translational modifications. Udeshi focuses on unbiased analyses to decipher signaling pathways and identify key regulatory proteins in biological systems that are associated with physiological disease or drug perturbation phenotypes. 

Udeshi has a strong focus in the area of protein ubiquitination and has developed proteomic methods for enrichment and quantification of ubiquitylation sites at a global scale, to detect ubiquitination from cell or tissue samples. The developed techniques have been critical for the identification of ubiquitin ligase substrates and have revealed key transcription factors modulated upon lenalidomide treatment in myeloma, as well as substrates targeted by recurrently mutated ligases in prostate cancer. Udeshi also uses, develops, and applies methods to identify proteins in a spatial context using enzyme-mediated proximity labeling. 

Udeshi completed her Ph.D. in chemistry from the University of Virginia under the direction of Donald F Hunt. She joined the Broad Institute in 2009 as a postdoctoral associate. Udeshi holds a B.A. in both chemistry and economics from Boston University.

Udeshi is the recipient of the Broad Institute Excellence Award and she is an Adelson Medical Research Foundation Investigator. She has been recognized by Clarivate Analytics as one of the most highly cited scientists in the world in biology and biochemistry in 2022.

October 2023